In the first part, we summarize the general information regarding (i) the role of LDL-C in atherosclerotic cardiovascular disease (ASCVD), (ii) data regarding the role of PCSK9 in cholesterol metabolism, (iii) pleiotropic effects of PCSK9, and (iv) the effects of PCSK9 silencing. This evidence concerns the gene PCSK9 and atherosclerosis.