On the contrary, in normal healthy cells, the PKR pathway is on, and the production of viral particles, and therefore viral replication, are inhibited [131]; and (v) cancer cells can also expose on their surface viral entry receptors, e.g., nectin and herpesvirus entry mediator (HVEM), used by HSV, which are overexpressed in melanoma and different carcinoma [132]. Here, EIF2AK2 is linked to cancer.