It was previously reported that treatment with the membrane-permeable zinc chelator N,N,N’,N’,-tetrakis(2-pyridylmethyl) ethylenediamine (TPEN) induced depletion of XIAP at the posttranslational level in human PC-3 prostate cancer cells while sensitizing these cells to TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis [18]. This evidence concerns the gene TNFSF10 and Familial prostate cancer.