As in humans, DN in rodents can be accelerated by concomitant induction of hypertension through the knockout of the endothelial nitric oxide synthase (eNOS) gene [32] or through the knock-in of the mouse Ren-2 gene in transgenic (mREN-2)27 rats called Ren-2 rats [33]. Here, NOS3 is linked to hypertensive disorder.