PLP1 and myeloid sarcoma: While the exact mechanism is less studied than that of HSP, animal models have shown that PLP1 mutations lead to apoptosis of oligodendrocytes (similar to T-lymphocyte mediated toxicity in MS) due to accumulation of PLP1 in the endoplasmic reticulum and the induction of the unfolded protein response (UPR), leading to demyelination and onset of MS-like symptoms [12,13].