While the pathogenesis of the disease is not entirely understood, MS is believed to stem in part from a T-cell mediated autoimmune process—inflammatory infiltrates dominated by MHC class 1 CD8+ T-cells seen in tissue biopsy of individuals with MS are thought to directly lead to oligodendrocyte damage and demyelination as a result of local inflammation [2]. The gene discussed is CD8A; the disease is myeloid sarcoma.