Through the engagement of cell surface receptors, interaction with other ECM molecules and release of growth factors/cytokines upon remodeling, the ECM significantly influences the behavior of tumor cells, as well as other tumor-associated cell types such as infiltrating leukocytes, vascular endothelial cells, pericytes, and lymphatic endothelial cells [28,65,66,67]. This evidence concerns the gene CD177 and neoplasm.