One important finding supporting a role of RNA interaction in TDP-43 proteinopathy is a cell study which found that the addition of RNA not only reduces TDP-43 aggregation, but also rescues TDP-43 cytotoxicity in cultured neurons over expressing wild type TDP-43 [75], demonstrating the potential of RNA as a chaperone for RBPs like TDP-43. Here, TARDBP is linked to proteostasis deficiencies.