The differential expression of IFNGR1, IFNGR2, Jak1, Jak2, and STAT from the entire series was analyzed; as expected, the normal cohort (n = 19) showed lower Jak2 mRNA expression than did the HCC (HCV-infected) cohort (n = 38), and the GSE121248 cohort showed the similar result that Jak1 mRNA expression is higher in HCC (HBV-infected, n = 70) than in the normal liver (n = 37; Figure 1B). This evidence concerns the gene JAK1 and hepatocellular carcinoma.