Clinical factors (tumor size, hypercalcemia and presence of regional lymph nodes metastases at the time of diagnosis) and histological features (Ki67 index, tumor pattern, necrosis, inflammatory infiltration, lymph vascular invasion, cellular pleomorphism) were investigated on the entire population (n = 35 dogs) and were correlated to ST and DFI in order to find a prognostic significance. The gene discussed is MKI67; the disease is Hypercalcemia.