Among them, several growth factors, such as epidermal growth factor (EGF), fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), transforming growth factor (TGF) and vascular endothelial growth factor (VEGF), have been widely recognized as master regulators of the interactions occurring within the tumor microenvironment [5]. This evidence concerns the gene EGF and neoplasm.