ACE and obesity due to melanocortin 4 receptor deficiency: Studies have shown that miR-145, along with miR-143, plays a role in controlling vascular homeostasis by regulating smooth muscle cell plasticity and responsiveness to the action of ACE (angiotensin-converting enzyme), which suggests a possible connection between the imbalance of miR-145/143 associated with obesity, increased cardiovascular risk, and poor blood pressure control, representing in this way a potential therapeutic target.