STAT3 and hepatocellular carcinoma: Tumor suppressive effects were observed in HCC, CRC, RCC, salivary gland carcinoma, thyroid cancer, laryngeal carcinoma, osteosarcoma, prostatic adenocarcinoma, melanoma, Ewing sarcoma, glioblastoma, gallbladder cancer through its action on mRNA genes, with effects on many pathways involved in carcinogenesis such as Wnt, PI3K/Akt, STAT-3, MAPK, NF-κB, p53 [175].