As prostate cancer progresses in the setting of MetS, CTBP1 increases, resulting in repression of miR-205-5p together with upregulation of oncomiRs, like: miR-19b-3p, miR-29c-3p, miR-30b-5p, miR-301a-3p, miR-454-3p [29]. This evidence concerns the gene CTBP1 and Familial prostate cancer.