MAPK8 and type 2 diabetes mellitus: In contrast, a study on animals showed that miR-125b expression is lower in the pancreatic cells of mice with T2D, but these presented a higher expression of DACT1, JNK, and c-Jun, demonstrating that miR-125b stimulates the increase of insulin sensitivity and pancreatic beta cell function through the inhibition of the JNK signaling pathway due to the suppressive effect on DACT1 [282].