Beside obesity, miR-27b may be upregulated by human papillomaviruses HPV16 E7 in cervical cancer tissue, which suppresses the expression of PPARγ and increases the level of oncogenic pH regulator, Na+/H+ exchanger isoform 1 (NHE1) [39]. The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.