SOX2 and neoplasm: Downregulation of this miR facilitates tumor progression, migration, angiogenesis, and survival through its action on several genes and molecular pathways involved in oncogenesis such as PI3K, KRAS, EGFL7, CRK, ADAM9, HOXA9, IRS-1, SOX-2, CADM1, PAX4, SLC7A5, and VEGF [176].