Because piRNA-823 is directly related to DNA methyltransferase 3A (DNMT3A) and 3B (DNMT3B) in myeloma cells, piRNA-823 inhibition using a piRNA-823 antagomir (antagomir-823) was shown to result in significant decreases in DNMT3A and DNMT3B expression. Here, DNMT3A is linked to plasma cell myeloma.