CXCR4 and plasma cell myeloma: According to further analysis from the same group, compared with HD BM-MSC decellularized ECM, myeloma cells cultured on MM BM-MSC ECM show activated MAPK/TI, proliferation, migration, invasion, epithelial-to-mesenchymal transition (EMT), and C-X-C chemokine receptor 4 (CXCR4) expression in myeloma cells [51].