Because piRNA-823 is directly related to DNA methyltransferase 3A (DNMT3A) and 3B (DNMT3B) in myeloma cells, piRNA-823 inhibition using a piRNA-823 antagomir (antagomir-823) was shown to result in significant decreases in DNMT3A and DNMT3B expression. The gene discussed is DNMT3B; the disease is plasma cell myeloma.