ARCI originates from chronic synaptic dysfunction [96] and neuronal loss [97], which are accompanied by the formation of senile plaques, which are extracellular deposits of amyloid-β (Aβ), and neurofibrillary tangles, which are paired helical filaments of hyperphosphorylated Tau. Here, MAPT is linked to autosomal recessive congenital ichthyosis.