In summary, we report a previously unidentified mPCa cell-intrinsic mechanism, based on the Glo1/MG-H1/PD-L1 axis, by which cancerous cells elude CD8+ T-cell-mediated immune surveillance toward cancer progression and survival, thus suggesting that down-regulating Glo1 may become a promising therapy that, targeting tumor immune evasion, inhibits malignant growth of mPCa cells. This evidence concerns the gene CD8A and cancer.