Of note, in consideration of the growing importance of PD-L1/PD-1 axis as a target in anti-cancer immunotherapy and of the awareness of its failure in some solid malignancies, this research sets the stage for additional studies aimed at investigating Glo1/MG-H1/PD-L1 pathway in immunotherapy responses and malignant behaviors in broader cancer contexts. This evidence concerns the gene CD274 and cancer.