CD274 and cancer: In this study, we showed, for the first time, that Glo1, by limiting MG-H1 intracellular accumulation, prevents this specific MG-derived AGE to down-regulate PD-L1 expression in advanced metastatic cell models, all this resulting in PD-L1-mediated inhibition of cytotoxic CD8+ T cells, and consequent promotion of tumor immune evasion, with concomitant cancer progression (Figure 9).