Loss of SUZ12 in type 1 and type 2 deletions may promote MPNST development in NF1-deleted patients through its role in the polycomb repressive complex 2 (PRC2): recent advances in genomic studies of MPNSTs identified critical involvement of PRC2 core components SUZ12 and EED in transition to malignancy [77,78,79]. Here, EED is linked to malignant peripheral nerve sheath tumor.