TYR and melanoma: Figure 7A shows PCA analysis of cytokines/chemokines including TYR. It can be observed that the three most relevant components are able to distinguish and cluster melanoma from control cases with high efficacy. On the contrary, PCA analysis performed using the same dataset but in the absence of TYR (Figure 7B) shows a lower ability to discriminate the two groups according to a three-dimensional spatial distribution, confirming a crucial role of TYR in immunomodulatory signals secretion by human MICs upon Caff treatment.