The use of 15d-PGJ2 in patients undergoing radical nephrectomy for renal cell carcinoma caused apoptosis of tumor cells through the caspases pathway and the activation of JNK (c-Jun N-terminal kinase) and AKT kinases, associated with an increase in intracellular calcium, and independently of the activation of the PPARγ pathway [35]. The gene discussed is MAPK8; the disease is neoplasm.