Treatment of human breast cancer MCF-7 cells with 15d-PGJ2 induced EMT as evidenced by increased expression of Snail (zinc finger transcriptional repressor) and ZEB1 (zinc finger E-box-binding homeobox 1), with concurrent down-regulation of E-cadherin and production of CXCL8 (chemokine (C-X-C motif) ligand 8) as a putative activator of fibroblasts, which may contribute to tumor-stroma interaction in inflammatory breast cancer microenvironment [50]. This evidence concerns the gene ZEB1 and breast cancer.