PTGS2 and neoplasm: The use of 3-(3-methylthiophen-2-yl)-5-(3,4,5-trimethoxyphenyl) isoxazole (2b) showed significant inhibitory activity toward COX-2 and showed a good inhibition of tumor growth, peritoneal angiogenesis, and ascites formation in Ehrlich ascites carcinoma (EAC) cell mouse model [106].