Also, overexpression of the enzyme prostacyclin synthetase (PGIS) in lung cancer cell lines and mouse models has been shown to inhibit MHC-II (major histocompatibility complex-II)+ lung cancer growth, independently of PGI2, through recruitment of T-CD4 (cluster of differentiation 4)+ lymphocytes [56]. Here, PTGIS is linked to lung carcinoma.