NSAIDs inhibit tumor DNA synthesis, modulate ER concentration and the COX, NF-κB, caspases and WNT (wingless and Int-1)-β-catenin-TCF4 (transcription factor 4) pathways, as well as glycogenesis, by inactivating 6-phosphofructose-1-kinase) [44]. The gene discussed is TCF4; the disease is neoplasm.