In recent years, the perspective for designing innovative IBD therapies is changing, readdressing the attention from a paradigm aimed at “fighting inflammation,” mainly via non-biological (i.e., aminosalicylates, thiopurines, and steroids) or biological therapies (mainly acting on TNF, IL-23, or adhesion molecules), toward a novel pharmacological approach aimed at “targeting and advancing inflammation resolution” [23]. The gene discussed is TNF; the disease is inflammatory bowel disease.