FIG4 and inflammatory bowel disease: Noteworthy, FIG4 has a role as a regulatory complex of both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), whose metabolism has been suggested to be an unexpected and critical link between membrane trafficking in intestinal epithelial cells and the pathogenesis of inflammatory bowel disease [21].