Our compound of choice {4-iodo-2-(3-(p-tolyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)phenol = 4-MMI} [19] was found to efficiently inhibit heparanase enzymatic activity, cell invasion, experimental metastasis, and tumor growth in mouse models. The gene discussed is HPSE; the disease is neoplasm.