A mutation is a “DNA a population when the observed variation from individual to individual is not maintained by recurrent mutation.” Therefore, based on the above concepts of clinical genomics, the importance of NLRP3 inflammasome and CARD8 gene as potential biomarkers will explain that these genes are highly specific and conserved in inflammatory diseases such as periodontitis and coronary heart disease [6]. The gene discussed is CARD8; the disease is periodontitis.