AQP8 and Infertility: Three of the 66 variants affected three genes previously associated with infertility: variant c.181G > C (p.Ala60Pro) of mutS homolog 3 (MSH3) in 15 cases, c.1534G > A (p.Val512Ile) in gamma-glutamyltransferase 1 (GGT1) in 14 cases, and c.782G > A (p.Arg261Gln) of aquaporin 8 (AQP8) in 13 cases (as noted in Table 1).