Single-cell microarray analysis of circulating tumor cells (CTCs) isolated from peripheral blood and disseminated tumor cells (DTCs) isolated from bone marrow aspirates of breast cancer patients [38] (GEO accession GSE27574) reveals that DTCs have a decrease in copy number of ITGA2 and ITGB1 compared to primary breast tumor samples and CTCs (Figure 4D). The gene discussed is ITGB1; the disease is breast carcinoma.