Spearman correlation analysis of gene signatures in metastatic biopsies of breast cancer reveal a significant (p < 0.001) negative correlation between PTHLH and ITGA2 (p < 0.001), PTHLH and ITGB1 (p < 0.01), Gli2 and ITGA2 (p < 0.001), and Gli2 and ITGB1 (p < 0.0001) (Figure 5C,D). The gene discussed is ITGA2; the disease is breast cancer.