Whole exome sequencing from the Metastatic Breast Cancer Project [39,40] was analyzed for putative copy number alterations of ITGA2 and ITGB1 in biopsies of primary tumors with no evidence of metastatic disease (non-metastatic primary), biopsies of bone metastases, and biopsies of soft tissue metastases (Figure 4E). This evidence concerns the gene ITGA2 and breast cancer.