Although, in rat models, Myo treatment seems not to protect microvascular vessels (glomerular and retinal vasculature) from diabetes-induced changes [41], D’Oria and colleagues showed in human endothelial cells that inositols activate PKB/Akt and MAPK/ERK pathways, potentially promoting cell survival and cellular metabolism [42]. The gene discussed is AKT1; the disease is diabetes mellitus.