BAP1 and neoplasm: Instead, major genomic alterations affect a series of tumor-suppressor genes in human MM, e.g., the BRCA1-associated deubiquitylase (BAP1), the cyclin-dependent kinase inhibitor 2A/B (CDKN2AB), neurofibromatosis type 2/moesin-ezrin-radixin-like protein (NF2/Merlin), and tumor protein 53 (TP53).