RAGE-mDia1 signaling also mediates the activations of Rac1 and Cdc42 during C6 glioma cell migration [15], and RAGE-mDia1 activates PKCβII, ERK1/2, and JNK signaling and regulates Egr-1 in hypoxic macrophages [158]. The gene discussed is DIAPH1; the disease is central nervous system cancer.