RAGE is also involved in the progression of pancreatic cancer in vitro and in vivo via the expressions of MMP2, MMP-9, NF-κB, and vascular endothelial growth factor (VEGF) [201], and in H1975 cells (a non-small cell lung cancer (NSCSLC) cell-line) was found to enhance growth, metastasis, and EMT (epithelial-mesenchymal transition) by activating the P13K/AKT and KRAS/RAF-1 pathways. The gene discussed is VEGFA; the disease is non-small cell lung carcinoma.