Interactions between RAGE and S100 proteins or HMGB1 are involved in melanoma progression and metastasis [195], and the AGE/RAGE pathway was found to increase the phosphorylation of ERK and promote tumor progression, invasion, and metastasis in gastric cancer via the RAGE/ERK/Sp1/MMP2 pathway [196]. The gene discussed is HMGB1; the disease is neoplasm.