The release of HMGB1 from dying cancer cells enhances regrowth and chemoresistance via RAGE-ERK signaling, and the RAGE-ERK pathway activates the phosphorylation of Drp1 at residue S616, thus triggering autophagy for chemoresistance and regrowth in surviving colorectal cancer cells [148]. The gene discussed is HMGB1; the disease is cancer.