CD4 and obesity due to melanocortin 4 receptor deficiency: It is well know that systemic inflammation correlates to obesity, characterized by the presence of CD4 and CD8 T cell infiltration and modified immune response, which contributes to the development of obesity related diseases and metabolic disorders like dyslipidemia, type 2 diabetes (T2DM), and cardiovascular pathologies already in pediatric age [5,6].