Recent studies indicated that some regulators of FA metabolism, such as peroxisome proliferator-activated receptor α (PPAR-α) and sirtuin-1 (SIRT1), are targets of several miRNAs [62,63], suggesting that certain epigenetic mechanisms may also contribute to NAFLD-related hepatic lipid alterations. Here, SIRT1 is linked to metabolic dysfunction-associated steatotic liver disease.