Constitutive activation of PC1-p30 (a proteolytic fragment of PC1 corresponding to the cytoplasmic tail)/Src/STAT3 pathways would be amplified after integrating signaling inputs from EGF and cAMP, and lead to aberrant proliferation of renal epithelial cells and cyst growth in ADPKD [109]. Here, EGF is linked to autosomal dominant polycystic kidney disease.