Genetic knockout of STAT3 and STAT6, STAT3 inhibitor S3I-201, STAT6 non-specific inhibitor teriflunomidelysine, methyltransferase SMYD2 specific inhibitor AZ505, or anti-parasitic compound pyrimethamine could attenuate ADPKD cell proliferation and reduce renal cyst formation [108,110,111]. This evidence concerns the gene STAT3 and autosomal dominant polycystic kidney disease.