In this regard, WNT5A and JNK hepatic expression analysis in NAFLD human subjects is a novelty, but our results seemed to agree with other studies assessed in animal models, such as Wang J. et al., who observed that the WNT pathway could play a key role in hepatic stellate cell activation and proliferation that trigger liver regeneration [11]. Here, MAPK8 is linked to metabolic dysfunction-associated steatotic liver disease.