To deepen the knowledge of the role of SFRP5 in NAFLD pathogenesis, we wanted to analyze correlations between SFRP5 relative expression in the liver with different parameters such as weight, BMI, glucose, insulin, cholesterol, HDL-C, LDL-C, TG, and liver transaminases. The gene discussed is INS; the disease is metabolic dysfunction-associated steatotic liver disease.