VEGFA and glioblastoma: We recently characterized circSMARCA5 as a tumor-suppressive circRNA, downregulated in GBM tissue when compared to normal brain parenchyma; its expression is inversely correlated with: (i) overall and progression-free survival of GBM patients; (ii) pro- to anti-angiogenic VEGFA mRNA isoform ratio; and (iii) microvascular density of GBM tissue [31].