This is one of the first studies that focuses on circRNAs as non-invasive diagnostic biomarkers, detectable in GBM patients’ liquid biopsies: to the best of our knowledge, only Chen et al. published a paper on three plasmatic circRNAs (circFOXO3, circ_0029426, and circ-SHPRH) with a diagnostic value for GBM [49]. This evidence concerns the gene SHPRH and glioblastoma.