TRIB1 and neoplasm: The first report on the effect of TRIB1 downregulation in colorectal cancer cells was published in 2014, and showed that interfering with TRIB1 (cells stably transfected with shRNA vectors, specifically knocking down TRIB1 gene expression) led to the decrease of the number of double-minute chromosomes (DMs) formed, along with genomic instability and cytotoxic DNA damage in the NCI-H716 tumor cells [56].