Several studies have been published reporting the role of Tribbles proteins in different types of cancer, including TRIB1 in prostate [34], glioma [35], ovarian [36], and thyroid [37] cancers; TRIB2 in melanoma [38], lung [39], liver [40,41,42], acute leukemias [27,43,44], and glioblastoma [45]; and TRIB3 in lung [46], breast [47,48], renal [49], gastric [50], liver [51], retinoblastoma [52], glioblastoma [53], and ovarian [54] cancers; as well as all Tribbles members in colorectal cancer, as herein fully presented. This evidence concerns the gene TRIB3 and colorectal cancer.