TRIB3 and colorectal adenocarcinoma: The authors had identified SKIP3, a protein with very high homology to other previously reported mammalian orthologs of Drosophila tribbles [63], later named TRIB3. While in the normal tissues tested (including colon), TRIB3 mRNA levels were preferably elevated in liver, the highest expression was observed in tumor-derived cell lines, which included the colorectal adenocarcinoma SW480 cells [63].