Concerning variant recurrence, the heterozygous mutation in FGFR1 p.R285W (likely pathogenic; CM063987 HGMD), coexisting with another heterozygous variant CHD7 p.N1030H (pathogenic; novel), was recurring in two unrelated patients, both with reversal of hypogonadism. The gene discussed is FGFR1; the disease is hypogonadism.