It is known that hypoxic conditions, such as in injury, amyotrophic lateral sclerosis (ALS), carbon monoxide poisoning, respiratory arrest, low blood pressure or stroke, change the actin cytoskeleton structure by activation of mitogen-activated protein kinase (MAPK) and Rho Kinase signaling pathways in endothelial cells [74]. This evidence concerns the gene WNK2 and amyotrophic lateral sclerosis.