In particular, our group investigated the tolerogenic effect of PLGA-NPs loaded with the myelin oligodendrocyte glycoprotein (MOG)35–55 autoantigen and recombinant interleukin-10 (r IL-10), used as a tolerogenic adjuvant, in experimental autoimmune encephalomyelitis (EAE). The gene discussed is IL10; the disease is experimental autoimmune encephalomyelitis.