Cell culture studies showed that CVB3 selectively targets Kirsten rat sarcoma viral oncogene homology (KRAS)-mutant lung adenocarcinoma (A549, H23, H2030, and HPL1D cell line stably expressing KRASG12V) and TP53/RB1-mutant SCLC (H524 and H526 cells) cells, with limited impacts on normal lung epithelial cells (primary, BEAS2B, HPL1D, and 1HAEo cells) and epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma (HCC4006, PC9, H3255, H1975, and HPL1D cell line stably expressing EGFRL858R) [24,28]. Here, RB1 is linked to lung adenocarcinoma.