PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Patatin-like phospholipase domain protein 3 (PNPLA3) is one lipolytic enzyme in hepatocytes located on large lipid droplets and several studies have shown that the PNPLA3 rs738409 (I148M) variant is powerfully linked to hepatic damage in NAFLD, at different levels such as steatosis, necroinflammation and fibrosis [21,22].