Others include the role of miR-144 as a potential biomarker for predicting PC progression, by its interaction with EZH2, reducing cell viability and promoting cell apoptosis [5], or the role described for miR-145-5p in PC metastasis by binding TOP2A, which is indicated as a useful biomarker for metastatic PC detection [2]. The gene discussed is EZH2; the disease is pachyonychia congenita.