Others, such as neutrophil-to-lymphocyte ratio [53], DLX1, PCA3, and DUOX1 mRNA plasma expressions [54] or a 14-genes’ panel urine test including PMP22, GOLM1, LMTK2, EZH2, GSTP1, PCA3, VEGFA, CST3, PTEN, PIP5K1A, CDK1, TMPRSS2, ANXA3, and CCND1 [55], are some of the most updated research in PC non-invasive biomarkers. The gene discussed is DUOX1; the disease is pachyonychia congenita.