IL6 and plasma cell myeloma: In 2011, Singh et al. [49] showed that the novel vascular disrupting agent (VDA) plinabulin induced cell death in multiple myeloma cells, (MM.1S, MM.1R-dex resistant), RPMI-8226 (human myeloma cells), and INA-6 (IL-6-dependent) without affecting the viability of normal cells (PBMCs).