In addition, we found a near-significant association of the NOD2 rs2066844 risk allele with a history of IBD-related surgery (65.2% vs. 52.8%, p = 0.064; or, if corrected to the number of operations per disease year, 0.05 vs. 0.03, p = 0.091). This evidence concerns the gene NOD2 and inflammatory bowel disease.