Among 46 HIV+ patients, 25 presented concomitant infections, mainly syphilis and Molluscum contagiosum, and an increase of IFN-γ could well be associated with those manifestations (Figure S1A), as suggested by the observation that when these patients were excluded from statistical analysis, IFN-γ levels decreased in response to ART (Figure S1B). Here, IFNG is linked to molluscum contagiosum.