ACSBG1 and neurodegenerative disease: The shared neurodegenerative features in dABCD and bgm/dbb deficient flies show that the lipid metabolic pathway is a key component of the X-ALD-like neurodegenerative disease in Drosophila. More specifically, experiments achieved with bgm and dbb deficient flies indicate that the loss of metabolites is the cause of neurodegenerative disease rather than accumulation of substrates (V/LCFAs), as was commonly thought.