Only five (1.1%; 1 of 23 TCF3-PBX1-positive; 1 of 20 dic(9;20)-positive; 2 of 28 MLLr-positive; 1 of 5 hypodiploid) ALL samples (Figure 3D) and 16 (3.5%; 5 of 20 dic(9;20)-positive; 10 of 28 MLLr-positive; and 1 of 5 hypodiploid) ALL samples (Figure 3E) showed a relatively higher methylation level (≥10%) in the DR4 and the DR5 genes, respectively. This evidence concerns the gene PBX1 and acute lymphoblastic leukemia.