Next, we extensively evaluated mean percent methylation of six and five CG dinucleotides annotated to the promoter of the DR4 and DR5 genes and located in the TSS200 region, respectively, using the genome wide DNA methylation data in a large childhood BCP-ALL cohort study of NOPHO (GSE49031) [21]. This evidence concerns the gene TNFRSF10A and acute lymphoblastic leukemia.