In BCP-ALL cell lines, the methylation status of the DR4 and DR5 genes was associated with their mRNA and cell-surface expression levels and their rhsTRAIL sensitivities, indicating that epigenetic modification of the DR4 and DR5 genes due to hypermethylation is a mechanism for TRAIL resistance in BCP-ALL. Here, TNFRSF10B is linked to acute lymphoblastic leukemia.