In contrast, MLL (KMT2A)-rearranged (MLLr) acute lymphoblastic leukemia (ALL) cells, which are clinically resistant to the GVL effect [14], generally express very low or undetectable levels of DR4 and DR5, and, subsequently, are resistant to rhsTRAIL [15]. The gene discussed is KMT2A; the disease is acute lymphoblastic leukemia.