For instance, in response to AML stimuli, endothelial cells and adipocytes support leukemic growth and persistence by secreting granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), IL-6, and serving as a source of fatty acids [47,67]. This evidence concerns the gene CSF3 and acute myeloid leukemia.