The expression of some adhesion factors (e.g., CXCR4, VLA-4, CD44v6 the most common AML CD44 isoform, G protein-coupled receptor 56 (GPR56), and junctional adhesion molecule (JAM)-C) in AML cells/LSC was associated with poor patient survival and was found increased in specific risk groups (e.g., VLA-4 in non-high-risk pediatric and adult patients, and GPR56 at mRNA level in intermediate- and high-risk patients) [65]. This evidence concerns the gene CD44 and acute myeloid leukemia.