TFEB and preeclampsia: Hypoxia-induced endoplasmic reticulum stress, one of the reasons for preeclampsia, can negatively affect transcription factor EB (TFEB) expression and its nuclear translocation leading to the decreased expression of TFEB-regulated lysosomal proteins, like lysosomal-associated membrane protein 1 (LAMP1), LAMP2, and cathepsin D. Impaired lysosomal biogenesis and autophagy resulted in increased protein aggregate accumulation in the placenta, due to the lack of lysosomal components [41].