PRDM9 and osteosarcoma: On the other hand, other histone methyltransferase, such as NSD2, have been reported to negatively regulate apoptotic signaling, while enhancing CSC properties and chemoresistance in osteosarcoma cells through a mechanism mediated by H3K36me2 modifications in key apoptotic and pluripotency genes and the activation of ERK and AKT pathways [95].