SERPINH1 and malignant colon neoplasm: In this regard, it has been recently demonstrated that in colon cancer, stromal HSF1 drives the transcription of genes encoding matrix proteins (FN1, LAMA1), matrix enzymes (MMP7, MMP9), and matrix chaperones (SERPINH1/Hsp47), inducing ECM remodeling and leading to cancer progression [93].