ALK and pachyonychia congenita: ADC: adenocarcinoma; SCC: squamous-cell carcinoma; LCC: large-cell lung carcinoma; NEU: neuroendocrine carcinoma; SCLC: small-cell lung cancer; MIA: minimally invasive adenocarcinoma of the lung; PC: pulmonary pleomorphic carcinoma; EGFR: epidermal growth factor receptor; ALK: ALK Receptor Tyrosine Kinase; PDX: patient-derived xenograft.