In our study, attention is given to three transcription factors supported by strong experimental evidence, zinc finger E-box binding homeobox 1 (ZEB1), MYC proto-oncogene, bHLH transcription factor (MYC) and p53, which have been validated as regulators of several selected miRNA clusters in human CRC cell lines [33,34]. The gene discussed is ZEB1; the disease is colorectal carcinoma.