Acute exercise of moderate intensity and duration increases the plasma levels of the pro-inflammatory cytokines tumor necrosis factor α (TNFα) and intercellular adhesion molecule 1 (ICAM1), of prostaglandin E1 (PGE1) and prostaglandin E2 (PGE2) and of 16 hydroxyl-palmitate (16HPAL) in metabolic syndrome patients [6], pointing to a mild pro-inflammatory response of metabolic syndrome patients to acute exercise. The gene discussed is TNF; the disease is metabolic syndrome.