FLT4 and lymphedema: Although several genetic predisposition factors for lymphedema are also target genes of BMP signaling (e.g., KDR, FLT4, NRP2, GATA2) [255,256,257], and unlike the many cardiovascular diseases that result from unbalanced BMP signaling (Figure 3), there is no direct evidence yet for a BMP involvement in lymphatic diseases in humans.